Clinical Situation

Tests - Click on the links below to view further details.

eg. Arthritis, Still’s disease,
Myalgia, Polymyalgia

Possible SLE, Sjogren’s, Sicca syndrome, Scleroderma, CREST,
MCTD, Myositis, Polymyositis etc.

Rheumatoid Factor (RA)

Anti-nuclear antibody ( ANA )

ANA

SLE monitoring

ANA, anti-dsDNA

Eye disorders

RA, ANA,
Complement C3/C4 ( C3/C4 )

(Plus ANCA if clinically indicated)

Vasculitic diseases

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eg. Vasculitic rashes, Urticaria,
Raynaud’s, Leg ulcers,
Erythema Nodosum

If renal impairment present

RA, ANA, C3/C4

Add ANCA

Fibrosing alveolitis,
Pulmonary fibrosis

If upper respiratory tract granulomas or nasal perforations, Behcet’s etc.

RA, ANA

RA, ANA, ANCA

ARF, CRF, PAN, GN
Microscopic polyarteritis,
Wegener’s, Churg-Strauss
Henoch-Schonlein

Goodpasture’s

ANCA positive treatment monitoring

ANA, C3/C4, ANCA
( If ANCA positive, MPO and PR3 antibodies will be performed by laboratory )

Anti-glomerular basement membrane antibody ( GBM )

MPO, PR3

eg Recurrent miscarriage, IUD
Unexplained thrombocytopaenia,
DVT/PE, CVA in the young or multi infarct dementia,
Livedo Reticularis,
Hughes’ syndrome

ANA, Anticardiolipin

Possible PBC, CAH,
Autoimmune hepatitis ( AIH )
Sclerosing cholangitis

ANA, Anti smooth muscle, mitochondrial and microsomal antibodies.

eg. Diarrhoea, Malabsorption,
? Coeliac etc.

? Pernicious Anaemia

Anti-tissue transglutaminase
( TTGA )

Gastric Parietal cell antibody

Bullous skin disorders
Pemhigoid, Pemphigus

Dermatitis Herpetiformis

Pemphigoid and Pemphigus antibodies

TTGA

Thyroid disorders, eg Hypothyroidism,
Thyroiditis ( if diagnosis unclear and required
for management decision )

Polyendocrinopathy

Adrenal, TPO, Gastric parietal cell antibodies

eg. Weakness, Myasthenia Gravis

Acetylcholine receptor antibodies

Allergic disorders

IgE

Specific IgE ( RAST ) if specific allergen suspected.
Allergens required to be tested MUST be stated.