Clinical Situation
| Tests - Click on the links below to view further details. |
| Rheumatic Diseases | |
eg. Arthritis, Still’s disease,
Myalgia, Polymyalgia
Possible SLE, Sjogren’s, Sicca syndrome, Scleroderma, CREST,
MCTD, Myositis, Polymyositis etc. | Rheumatoid Factor (RA)
Anti-nuclear antibody ( ANA )
ANA |
SLE monitoring | ANA, anti-dsDNA |
Eye disorders
| |
eg. Iritis, Scleritis, Uveitis,
central retinal vein occlusion | RA, ANA,
Complement C3/C4 ( C3/C4 ) (Plus ANCA if clinically indicated) |
Vasculitic diseases
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eg. Vasculitic rashes, Urticaria,
Raynaud’s, Leg ulcers,
Erythema Nodosum If renal impairment present | RA, ANA, C3/C4 Add ANCA |
| Respiratory disorders | |
Fibrosing alveolitis,
Pulmonary fibrosis
If upper respiratory tract granulomas or nasal perforations, Behcet’s etc. | RA, ANA
RA, ANA, ANCA |
| Renal Disease | |
ARF, CRF, PAN, GN
Microscopic polyarteritis,
Wegener’s, Churg-Strauss
Henoch-Schonlein
Goodpasture’s ANCA positive treatment monitoring | ANA, C3/C4, ANCA
( If ANCA positive, MPO and PR3 antibodies will be performed by laboratory ) Anti-glomerular basement membrane antibody ( GBM ) MPO, PR3 |
| Antiphospholipid Disorder’s | |
eg Recurrent miscarriage, IUD
Unexplained thrombocytopaenia,
DVT/PE, CVA in the young or multi infarct dementia,
Livedo Reticularis,
Hughes’ syndrome | ANA, Anticardiolipin |
| Liver Disorders | |
Possible PBC, CAH,
Autoimmune hepatitis ( AIH )
Sclerosing cholangitis | ANA, Anti smooth muscle, mitochondrial and microsomal antibodies. |
| GI disorders | |
eg. Diarrhoea, Malabsorption,
? Coeliac etc. ? Pernicious Anaemia | Anti-tissue transglutaminase
( TTGA ) Gastric Parietal cell antibody |
| Dermatological disorders | |
Bullous skin disorders
Pemhigoid, Pemphigus Dermatitis Herpetiformis | Pemphigoid and Pemphigus antibodies TTGA |
| Endocrine disorders | |
Thyroid disorders, eg Hypothyroidism,
Thyroiditis ( if diagnosis unclear and required
for management decision ) | Anti-Thyroid peroxidase antibodies
( Anti-TPO ) |
| Addison’s | Adrenal, TPO antibodies |
| Primary ovarian failure | Ovarian antibodies |
Polyendocrinopathy | Adrenal, TPO, Gastric parietal cell antibodies |
| Muscle Disorders | |
eg. Weakness, Myasthenia Gravis
| Acetylcholine receptor antibodies |
| Idiopathic cardiomyopathy, myocarditis | Cardiac muscle antibodies |
Allergic disorders | IgE Specific IgE ( RAST ) if specific allergen suspected.
Allergens required to be tested MUST be stated. |
